New Steroid Studies Are a Missed Opportunity for Concrete Answers About Covid-19 Treatment
While the data suggests a benefit from the drugs, the research was cut short
In June, scientists in England trumpeted good news about Covid-19: A simple steroid called dexamethasone reduced the death rate by 36% in people with severe cases of Covid-19 who were hospitalized and on ventilation. A month later, a paper published in the New England Journal of Medicine provided the data to back up the claim.
Three new studies out of Brazil, France, and the United States, published today in the Journal of the American Medical Association (JAMA), attempted to expand upon this research and strengthen the evidence. However, all of the studies were deliberately cut short in June upon the issuance of the British press release. As a result of being ended prematurely, the clinical trials testing dexamethasone and another steroid, hydrocortisone, in severely ill Covid-19 patients show positive but statistically nonsignificant findings because they didn’t have enough people enrolled to conduct adequate comparisons.
Fortunately, a meta-analysis, also published today in JAMA, run by the World Health Organization, that looked at seven clinical trials of corticosteroids for Covid-19 — the four studies listed…
