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A Nasal Spray Vaccine Could Be Key to Stopping the Spread of Covid-19
It would provide a first-line defense against the virus
Covid-19 vaccines are incredibly good at preventing severe symptoms and hospitalization, but they’re probably less effective at stopping transmission. To do that, we might need a different kind of vaccine altogether.
Because SARS-CoV-2 is mainly transmitted through droplets and airborne aerosols, some scientists reason that a vaccine should provide first-line protection where the virus typically enters the body — the nose. A Covid-19 vaccine that’s sprayed into the nose may not only prevent people from getting sick in the first place but also stop them from spreading the virus to others.
“When you get Covid-19, you don’t get injected with the virus. You get it in your respiratory tract,” Matt Memoli, MD, a virologist at the National Institute of Allergy and Infectious Diseases, tells the Coronavirus Blog. “So, you don’t need antibodies in the blood to prevent infection there. You need antibodies at the site of infection at the mucus membranes, at the airways.”
All vaccines are designed to spur the production of protective immune proteins called antibodies. Most vaccines are injected into the muscle, which stimulates serum antibodies that circulate in the…
